Conventional pituitary irradiation is effective in normalising plasma IGF-I in patients with acromegaly
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چکیده
منابع مشابه
Conventional pituitary irradiation is effective in normalising plasma IGF-I in patients with acromegaly.
OBJECTIVE For patients in whom acromegaly persists despite pituitary surgery, conventional pituitary irradiation represents an additional treatment option. A 30-60% cure rate is described in the literature, but these studies did not utilise strict rules of remission, such as "safe" GH levels <2.5 microg/l, and age-adjusted normal IGF-I levels. DESIGN AND METHODS We report the outcome of 41 pa...
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The pituitary-Thyroid axis of 12 Acromegalic patients was evaluated by measurement of the concentration (Total and free of thyroxine T4, T3 and revers T3 (rT3) and TSH, GH and prolactin before and after in stimulation with TRH. Using an ultrasensitive method of TSH measurement (IRMA) basal serum TSH levels of patients (0.76, 0.07-l.90mlU/L) were found slightly but significantly (P < 0.01), low...
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OBJECTIVE Most patients with acromegaly require additional treatments after trans-sphenoidal surgery. Although traditional methods of treatment aim at suppressing GH hypersecretion from the pituitary tumor, recent studies on the use of the GH receptor antagonist have shown that targeting the action of GH on peripheral tissues may be more effective. Estrogens and the selective estrogen receptor ...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2001
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1440109